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كل من يرى هذه الكلمات
أدعُ بصدقِ المخبتين المخلصين لأهلنا في غزة
اللهم فرج كربهم وانصرهم خير النصر وأحسنه واخذل من خذلهم وباع قضيتهم؛ آمين.

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Abdominal pain in pediatric population.


Evaluation of Thrombocytosis:

1. CBC and blood smear should be obtained to evaluate platelet morphology and concurrent presence of anemia, leukemic blasts, or leukoerythroblastic features.
2. Patients with unexplained vasomotor symptoms (erythromelalgia, flushing, pruritus), constitutional symptoms, thrombosis at unusual or multiple sites, and/or splenomegaly should be evaluated for potential myeloproliferative neoplasm.


Keep in mind






Predictors of poor outcome in comatose patients after CPR


Test yourself then see the explanation of the correct answer:

The vomiting without diarrhea displayed by the 10-month-old in the vignette, along with a full anterior fontanelle in the face of mild dehydration, points to an intracranial process. In addition, the child is exhibiting posturing, not a seizure, from continued overhydration and worsening intracranial pressure following the saline administration. Accordingly, administration of intravenous dexamethasone, along with other measures to treat increased ICP, is most appropriate. Treatment with prochlorperazine will only mask the child’s vomiting. Administration of fosphenytoin or lorazepam is not indicated in the absence of seizures. Continued aggressive hydration will worsen this child’s ICP.


It's an important question in practical life as a pediatrician😁


Of the following, the MOST appropriate next step in the management of this child is administration of:
Poll
  •   A. additional intravenous normal saline bolus of 20 mL/kg
  •   B. intravenous dexamethasone of 1 mg/kg
  •   C. intravenous fosphenytoin bolus at 20 mg/kg phenytoin equivalents over 10 minutes
  •   D. intravenous prochlorperazine of 5 mg
  •   E. rapid intravenous lorazepam of 0.05 mg/kg
225 votes


Question 🌟

A mother brings her 10-month-old son to the emergency department because he has been vomiting for the past 10 days. The child has not experienced any diarrhea. On physical examination, he is lethargic and has dry mucous membranes, reduced tears, a full anterior fontanelle, and 2-second capillary refill. After a second intravenous bolus of 20 mL/kg of normal saline, the boy extends his arms and legs forcefully for 10 seconds.
Of the following, the MOST appropriate next step in the management of this child is administration of


#Prep_pearls

Normal mean cell volume values also vary by age. A normal value in a newborn is high, up to 110 fL at birth, decreasing to 70 to 74 fL at ages 6 months to 6 years. The mean cell volume provides valuable information in determining the cause of anemia in infants and children.


#Prep_pearls

The most important steps in treating DIC are to find and treat the cause and correct the shock, acidosis, and hypoxia that complicate DIC. If these problems can be controlled, the bleeding quickly stops. Blood components, such as platelets, cryoprecipitate, or fresh frozen plasma, also may be required to help stop the hemorrhage. Continuous intravenous infusion of heparin and administration of specific factor concentrates (eg, activated protein C) are not used routinely in children.


#Prep_pearls

Common laboratory abnormalities in DIC include thrombocytopenia and prolonged prothrombin and partial thromboplastin times. Degradation of fibrinogen results in low serum fibrinogen concentrations as well as the presence of fibrinogen degradation products (eg, Ddimers)


#Prep_pearls

DIC is characterized by the consumption of clotting factors, anticoagulant proteins, and platelets.
This process leads to widespread intravascular deposition of fibrin, which results in tissue ischemia and necrosis, generalized hemorrhage, and hemolytic anemia. Venipuncture sites frequently bleed, and there may be a petechial, purpuric, or even ecchymotic rash. Tissue necrosis can involve virtually any organ.


Aniridia is defined as complete or partial iris hypoplasia (Item C231), often associated with foveal hypoplasia and reduced visual acuity.
the red reflex may appear unusual in shape or is too large due to the lack of intervening iris tissue. Infants who have such a finding should be referred to ophthalmology for confirmation and further delineation of the defect.

In such cases, it is important to follow a regular surveillance protocol for Wilms tumor that includes regular urinalysis and routine renal ultrasonography.


To remember:⭐️

1)Neutrophils disorders ( leukocyte adhesion deficiency):
Associated with recurrent bacterial skin and soft tissue infections, and gingival or periodontal disease

2)Congenital deficiencies of primary complement components: may present with severe or recurrent encapsulated bacterial (Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, disseminated Neisseria gonorrhoeae) infections or autoimmune disease.

3)Immunoglobulin deficiencies: typically present with recurrent or severe respiratory tract bacterial infections, sepsis, or meningitis

4)IL-12 receptor deficiencies:
are very rare and have been associated with disseminated nontuberculous mycobacterial infections, tuberculosis, and Salmonella infection.

5)T-cell subset deficiencies:
are associated with severe viral, fungal, or Pneumocystis infections.


#Prep_pearls

Initial evaluation of an adolescent or older child presenting with bone pain and swelling, especially with a palpable mass, should include:

o Plain radiographs (two views) of the suspected lesions, although no single feature on radiographs is diagnostic. Osteosarcomatous lesions can be purely osteolytic (about 30% of patients), purely osteoblastic (about 45% of patients), or a mixture of both. Elevation of the periosteum may appear as the characteristic Codman triangle. Extension of tumor through the periosteum may result in a so-called "sunburst appearance" (about 60% of patients).

o Both magnetic resonance imaging of the primary lesion and computed tomography scan of the chest are necessary to confirm the diagnosis and for staging purposes. Such scans frequently are performed at the tertiary center using their protocols.


#Prep_pearls

Osteosarcoma is the third most common cancer in adolescence, after lymphomas and brain tumors

Never ever forget the view of osteosarcoma on x-ray!


Question: ⭐️
A 3-year-old boy is referred to you for evaluation of his third episode of soft-tissue infection. You note that he was hospitalized at 1 year of age for a perirectal infection requiring incision and drainage, and his umbilical cord detached at 8 weeks of age. On physical examination, his temperature is 39.3°C, he has an approximately 5-cm area of erythema with central necrosis over his left lateral thigh, and his gums are markedly inflamed. His white blood cell count is
42.0x103/mcL (42.0x109/L), with 80% neutrophils, 3% bands, and 17% lymphocytes.


You suspect a primary immunodeficiency disorder. Of the following, the immunodeficiency is MOST likely related to a defect in function or number of :
Poll
  •   A. complement proteins
  •   B. immunoglobulins
  •   C. interleukin-12
  •   D. neutrophils
  •   E. T-cell subsets
30 votes

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