Forward from: Amir Hossein Loghman
#Meta_analysis
#Coronavirus
#COVID_19
Material and methods:
🔎 Search strategy:
An electronic search in Medline (PubMed interface), Scopus and Web of Science, using the keywords “procalcitonin” AND “2019 novel coronavirus” OR “2019-nCoV” OR “COVID-19” without date (i.e., up to March 3, 2020) and language restrictions
✅ Inclusion criteria:
Documents reporting data in COVID-19 patients with or without severe disease (defined as needing admission to intensive care unit or use of mechanical ventilation).
❌ Exclusion criteria:
Studies in which procalcitonin values were not reported in patients with or without severe COVID-19
⚠️ Procalcitonin values were entered as dichotomous variable, i.e., below or above the locally defined reference range (typically ≥0.50 ng/mL)
⚠️ Since the heterogeneity (I2 statistics) did not exceed 50%, a fixed effects model was finally used
Conclusion:
- Increased procalcitonin values are associated with a nearly 5-fold higher risk of severe SARS-CoV-2 infection (OR, 4.76; 95% CI, 2.74-8.29)
- The heterogeneity among the different studies was found to be modest (i.e., 34%)
@SRMEG_USERN
#Coronavirus
#COVID_19
Material and methods:
🔎 Search strategy:
An electronic search in Medline (PubMed interface), Scopus and Web of Science, using the keywords “procalcitonin” AND “2019 novel coronavirus” OR “2019-nCoV” OR “COVID-19” without date (i.e., up to March 3, 2020) and language restrictions
✅ Inclusion criteria:
Documents reporting data in COVID-19 patients with or without severe disease (defined as needing admission to intensive care unit or use of mechanical ventilation).
❌ Exclusion criteria:
Studies in which procalcitonin values were not reported in patients with or without severe COVID-19
⚠️ Procalcitonin values were entered as dichotomous variable, i.e., below or above the locally defined reference range (typically ≥0.50 ng/mL)
⚠️ Since the heterogeneity (I2 statistics) did not exceed 50%, a fixed effects model was finally used
Conclusion:
- Increased procalcitonin values are associated with a nearly 5-fold higher risk of severe SARS-CoV-2 infection (OR, 4.76; 95% CI, 2.74-8.29)
- The heterogeneity among the different studies was found to be modest (i.e., 34%)
@SRMEG_USERN