Aniridia is defined as complete or partial iris hypoplasia (Item C231), often associated with foveal hypoplasia and reduced visual acuity.
the red reflex may appear unusual in shape or is too large due to the lack of intervening iris tissue. Infants who have such a finding should be referred to ophthalmology for confirmation and further delineation of the defect.

In such cases, it is important to follow a regular surveillance protocol for Wilms tumor that includes regular urinalysis and routine renal ultrasonography.