Doctors In Training ( DIT )


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Весь мир, Английский
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Медицина
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Educational objective: Diabetic peripheral neuropathy is characterized by numbness and paresthesia in a stocking-and-glove distribution. It results from nonenzymatic glycosylation of proteins, leading to hyalinization of endoneurial arteries and ischemic nerve damage.
In addition, accumulation toxic substances within neurons results in deranged metabolism and increased oxidative stress.


This patient's neurological symptoms are most likely associated with which of the following features?
Опрос
  •   A. Endoneurial arteriole hyalinization
  •   B. Endoneurial inflammatory infiltration
  •   C.Mutation of a myelin protein gene
  •   D.Nerve compression within an anatomic compartment
  •   E. Poor signal transmission at the neuromuscular junction
348 голосов


A 62-year-old woman comes to the office due to tingling and numbness in her feet over the last several months. The patient has also noticed a small ulcer on her right foot that "doesn't seem to be healing." Medical history is significant for long-term diabetes, hypertension, and gout. Physical examination shows decreased pain sensation over both feet and bilateral absence of ankle reflexes.


Educational objective: Delayed cerebral ischemia due to cerebral vasospasm usually presents 3-12 days after the initial subarachnoid hemorrhage (SAH) with an acute change in mental status and/or new focal neurological deficits. Nimodipine, a selective calcium channel blocker, improves outcomes in patients with cerebral vasospasm by inducing cerebral vasodilation and decreasing calcium-dependent excitotoxicity.


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Which of the following medications could have most likely prevented the neurological complications this patient developed in the hospital?
Опрос
  •   A.ACE inhibitor
  •   B. Beta-adrenergic blocker
  •   C.Calcium channel blocker
  •   D.Central sympatholytic
  •   E. Nitrate
  •   F. Osmotic diuretic
  •   G.Thiazide diuretic
260 голосов




Educational objective: Creutzfeldt-Jakob disease is a prion disease characterized by rapidly progressive dementia, myoclonus, and death within a year of symptom onset.It is caused by the accumulation of an abnormally folded (ie,beta pleated sheet) protein that is resistant to proteases and can trigger similar conformational changes in other normally folded proteins.


Histologic analysis of the patient's brain tissue would most likely show accumulation of which of the following?
Опрос
  •   A. Alpha-synuclein
  •   B.Amyloid precursor protein
  •   C.Phosphorylated tau
  •   D. Protease-resistant protein
  •   E.RNA virus
201 голосов


A 57-year-old man is hospitalized for aspiration pneumonia. The patient was healthy and worked as an engineer without difficulty until about 4 months ago. Since that time, he has developed severe confusion, mood changes, and memory impairment and had to take medical leave from work. The patient is now completely dependent on his wife for toileting, feeding, and general self-care. Physical examination shows disorientation and sporadic, jerky extremity movements. During hospitalization, the patient lapses into a coma and dies. Postmortem examination of his brain shows widespread atrophy of the cerebral cortex and cerebellum.


Educational objective: Schwannomas present histologically with a biphasic pattern of cellularity (Antoni A and B areas) and S-100 positivity (indicating neural crest origin). Schwannomas can arise from the peripheral nerves, nerve roots, and cranial nerves (except CN II and CN I). Acoustic neuromas are the most common type of intracranial schwannoma and are located at the cerebellopontine angle at CN VIII.


Which of the following is the most likely diagnosis?
Опрос
  •   A. Glioblastoma
  •   B. Meningioma
  •   C.Metastatic lung adenocarcinoma
  •   D.Optic glioma
  •   E. Schwannoma
170 голосов


An intracranial mass is removed from a 33-year-old patient. The mass is composed of cells that have elongated, wavy nuclei. A biphasic pattern of growth is identified, consisting of areas of dense cellularity interspersed with less dense myxoid regions. The cells show diffuse S-100 immunoreactivity.


Educational objective: Lesions of the jugular foramen can result in jugular foramen (Vernet) syndrome, which is characterized by the dysfunction of cranial nerves IX, X, and XI. Symptoms include dysphagia, hoarseness, loss of gag reflex on the ipsilateral side, and deviation of the uvula toward the normal side.


A lesion involving which of the following anatomical structures is most likely responsible for this patient's symptoms?
Опрос
  •   A. Cerebellopontine angle
  •   B. Foramen magnum
  •   C.Foramen ovale
  •   D.Foramen rotundum
  •   E. Hypoglossal canal
  •   F. Jugular foramen
143 голосов


A 67-year-old woman with a known history of lung cancer comes to the office due to hoarseness and
difficulty swallowing. She has no disturbances in vision or hearing. On examination, there is loss of the gag reflex on the left side; when the patient is prompted to say "ah," the uvula deviates to the right side.
a right lower lobe lung mass and several osteolytic rib lesions. MRI of the head also demonstrates multiple Her left shoulder is drooped and strength is reduced during left shoulder shrug testing. Chest x-ray shows
lesions consistent with metastasis.


Educational objective: Germinomas are the most common pineal gland tumor and present with obstructive hydrocephalus and dorsal midbrain (Parinaud) syndrome. Germinomas in the suprasellar region cause endocrinopathies due to pituitary/hypothalamic dysfunction.


Which of the following is the most likely location of the brain lesion in this patient?
Опрос
  •   A
  •   B
  •   C
  •   D
  •   E
  •   F
140 голосов

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