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SRMEG

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SRMEG: Systematic Review and Meta-analysis Expert Group
A platform for exchange of knowledge covering the most recent of which will affect the development of systematic studies.
SRMEG discussion group https://t.me/joinchat/BMqX-02tPGidFTsTcStiig

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SRMEG

18 Mar 2020, 20:36

Репост из: Amir Hossein Loghman

#Hand_hygiene
#Facemask
#Prevention

❓ Does adherence to personal protective measures (e.g. hand hygiene or wearing of facemask) prevent pandemic diseases like influenza?

🔶 Developing a specific treatment or vaccine for a novel disease is a long and time consuming process, indicating the necessity of Personal protective measures as inexpensive method to prevent future pandemics in early stages

🔷 Meta-analyses of 16 studies suggest that:

✅ Regular hand hygiene provided a significant protective effect (OR = 0.62; 95% CI 0.52–0.73; I2 = 0%) against 2009 pandemic influenza infection
❎ Facemask use provided a non-significant protective effect (OR = 0.53; 95% CI 0.16–1.71; I2 = 48%) against 2009 pandemic influenza infection

🔴 Results suggest that campaigns to increase the frequency of hand hygiene, alongside use of facemasks in situations with a high risk of exposure, are likely to contribute to preventing pandemic influenza infection

https://www.sciencedirect.com/science/article/pii/S1755436516300858?via%3Dihub

@SRMEG_USERN

Effectiveness of personal protective measures in reducing pandemic influenza transmission: A systematic review and meta-analysis

The goal of this review was to examine the effectiveness of personal protective measures in preventing pandemic influenza transmission in human popula…

224 0 0

SRMEG

17 Mar 2020, 20:35

#Love
#Money
#Brain
#Reward

⚖️ Which is More Important in Life: Love or Money ⁉️

🔶 As social beings, human behavior is strongly motivated by social rewards: adults purchase luxurious products to draw attention and admiration of others, adolescents devote a lot of time in video games for higher virtual social status, and children finish their homework with the expectation of being praised.

🔶 Money is also an effective reward and primary motivation that derives human actions.

🔷 Meta-analyses show that social and monetary reward anticipation engage a common neural circuit consisting of the ventral tegmental area, ventral striatum, anterior insula, and supplementary motor area.

🔴 In this manner, love is analogous to money in human brain.

@SRMEG_USERN

https://www.sciencedirect.com/science/article/abs/pii/S0149763418307772

239 0 0

SRMEG

15 Mar 2020, 20:30

#BMI
#Egg
#Cardiovascular
#Statins

Eggs: Healthy or Not ⁉️

🔶 Eggs are a major source of dietary cholesterol, but they are also an affordable source of high quality protein, iron, unsaturated fatty acids, phospholipids, and carotenoids.

🔷 Meta-analysis of three cohorts (>5.54 million person years) shows that consumption of at least one egg per day is NOT associated with risk of cardiovascular diseases

🔷 Meta-analysis of prospective cohort studies (1720108 participants) indicates that an increase of one egg per day is NOT associated with risk of cardiovascular diseases, coronary heart disease, and stroke

🔵 Meta-analyses stratified by geographical location make a very intersting point that up to one egg per day:

❎ is NOT associated with cardiovascular disease risk overall
✅ is associated with potentially LOWER cardiovascular disease risk in Asian populations

@SRMEG_USERN

https://www.bmj.com/content/368/bmj.m513

264 0 0

SRMEG

14 Mar 2020, 20:31

#N95
#Mask
#Effectiveness

N95 respirator OR Surgical mask ⁉️

🔶 Conflicting recommendations exist related to which facial protection should be used by health care workers to prevent transmission of acute respiratory infections, including pandemic influenza.

🔷 Meta-analysis of 6 clinical studies (3 RCTs, 1 cohort study and 2 case–control studies) indicates NO difference between N95 respirators and surgical masks in risk of👇

❎ laboratory-confirmed respiratory infection
❎ influenza-like illness
❎ reported workplace absenteeism

🔷 Meta-analysis of 23 surrogate exposure studies reveals to us that under laboratory experimental conditions, N95 respirators are associated with less 👇

✅ filter penetration
✅ face-seal leakage
✅ total inward leakage

@SRMEG_USERN

https://www.ncbi.nlm.nih.gov/pubmed/32167245

450 0 0

SRMEG

14 Mar 2020, 11:26

Репост из: NIIMA, Network of Immunity in Infection, Malignancy and Autoimmunity

❌Deadline for application:
March 15th, 2020

🔊Call for Application 2020: Contribution in Writing Review Papers and/or Book Chapters

✅There is an opportunity for USERN members, who previously attended scientific writing workshops and published papers, to apply for contribution in writing review papers and/or book chapters in one of the interest groups, supervised by Prof. Nima Rezaei

✏️To apply, please fill the form via the following link:
https://cutt.ly/gttbDqW

📧You will be contacted by early April, if your application is accepted.

@niima_usern
@srmeg_usern
@cip_usern
@usern_net

2.4k 0 0

SRMEG

11 Mar 2020, 20:31

Репост из: 🄼🄾🄷🄰🄼🄼🄰🄳🧬

🦠Potential Therapeutics:

Apart from the timely diagnosis of cases, the achievement of favorable clinical outcomes depends on the timely treatment administered.

A number of novel compounds, as well as therapeutics, licensed for other conditions appear to have in vitro efficacy against the 2019-nCoV.

there are currently no effective specific antivirals or drug combinations supported by high-level evidence.

https://www.mdpi.com/2077-0383/9/3/623

#systematic_review
#covid19
@SRMEG_USERN

248 0 0

SRMEG

11 Mar 2020, 20:31

Репост из: 🄼🄾🄷🄰🄼🄼🄰🄳🧬

💉Potential Vaccines: With the emergence of 2019-nCoV, there are about 15 potential vaccine candidates in the pipeline globally

https://www.mdpi.com/2077-0383/9/3/623

#systematic_review
#covid19
@SRMEG_USERN

198 0 0

SRMEG

11 Mar 2020, 20:31

Репост из: 🄼🄾🄷🄰🄼🄼🄰🄳🧬

🧬Diagnosis: RT-PCR play an important role in the diagnosis of 2019-nCoV.

commercial RT-PCR kit developed by the Beijing Genomic Institute is currently widely used in China and likely in Asia.

https://www.mdpi.com/2077-0383/9/3/623

#systematic_review
#covid19
@SRMEG_USERN

175 0 0

SRMEG

11 Mar 2020, 20:31

Репост из: 🄼🄾🄷🄰🄼🄼🄰🄳🧬

📚27 studies were used for the full review from 1,065 articles.
https://www.mdpi.com/2077-0383/9/3/623

#systematic_review
#covid19
@SRMEG_USERN

185 0 0

SRMEG

11 Mar 2020, 20:31

Репост из: 🄼🄾🄷🄰🄼🄼🄰🄳🧬

Study Identification and Selection:
🔎Databases: PubMed, Embase and Cochrane Library
🔑key words: “SARS”, “coronavirus”, “MERS”, “2019 Novel coronavirus”, “Wuhan virus” AND “drug”, “therapy”, “vaccine”, “diagnosis”, “point of care testing” and “rapid diagnostic test”.
😎2 independent reviewers each focusing on SARS, MERS, and 2019-nCoV and A third independent reviewer was engaged to resolve any conflicting article of interest.
🈳Language: English articles
⏰Time: between 1 December 2019 and 6 February 2020.
Protocol: PRISMA
https://www.mdpi.com/2077-0383/9/3/623

#systematic_review
#covid19
@SRMEG_USERN

186 0 0

SRMEG

11 Mar 2020, 20:31

Репост из: 🄼🄾🄷🄰🄼🄼🄰🄳🧬

Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review

https://www.mdpi.com/2077-0383/9/3/623

😒Since mid-December 2019 and as of early February 2020, the 2019 novel coronavirus (2019-nCoV) originating from Wuhan (Hubei Province, China) has infected over 25,000 laboratory-confirmed cases across 28 countries with about 500 deaths (a case-fatality rate of about 2%).

👨‍👩‍👦‍👦The 2019 novel coronavirus (2019-nCoV), a beta-coronavirus, forms a clade within the subgenus sarbecovirus of the Ortho-coronavirinae subfamily.

🏃Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak.

📛⛔️Coronaviruses have error-prone RNA-dependent RNA polymerases (RdRP), which results in frequent mutations and recombination events.

#systematic_review
#covid19

200 0 0

SRMEG

10 Mar 2020, 20:32

Репост из: Amir Hossein Loghman

#Meta_analysis
#Coronavirus
#COVID_19

Table 1 depicts main characteristics of the included studies. Laboratory data are reported as percent of patients with abnormalities defined according to the local reference ranges.

✅ Main laboratory abnormalities in patients with unfavorable progression of Coronavirus disease 2019 (COVID-19):

1️⃣ Increased white blood cell count
2️⃣ Increased neutrophil count
3️⃣ Decreased lymphocyte count
4️⃣ Decreased albumin
5️⃣ Increased LDH
6️⃣ Increased ALT
7️⃣ Increased AST
8️⃣ Increased total bilirubin
9️⃣ Increased creatinine
1️⃣0️⃣ Increased cardiac troponin
1️⃣1️⃣ Increased D-dimer
1️⃣2️⃣ Increased PT
1️⃣3️⃣ Increased procalcitonin
1️⃣4️⃣ Increased CRP

@SRMEG_USERN

211 0 0

SRMEG

10 Mar 2020, 20:32

Репост из: Amir Hossein Loghman

#Meta_analysis
#Coronavirus
#COVID_19

Figure 1: Meta-analysis of procalcitonin values

@SRMEG_USERN

194 0 0

SRMEG

10 Mar 2020, 20:32

Репост из: Amir Hossein Loghman

#Meta_analysis
#Coronavirus
#COVID_19

Material and methods:

🔎 Search strategy:
An electronic search in Medline (PubMed interface), Scopus and Web of Science, using the keywords “procalcitonin” AND “2019 novel coronavirus” OR “2019-nCoV” OR “COVID-19” without date (i.e., up to March 3, 2020) and language restrictions

✅ Inclusion criteria:
Documents reporting data in COVID-19 patients with or without severe disease (defined as needing admission to intensive care unit or use of mechanical ventilation).

❌ Exclusion criteria:
Studies in which procalcitonin values were not reported in patients with or without severe COVID-19

⚠️ Procalcitonin values were entered as dichotomous variable, i.e., below or above the locally defined reference range (typically ≥0.50 ng/mL)

⚠️ Since the heterogeneity (I2 statistics) did not exceed 50%, a fixed effects model was finally used

Conclusion:
- Increased procalcitonin values are associated with a nearly 5-fold higher risk of severe SARS-CoV-2 infection (OR, 4.76; 95% CI, 2.74-8.29)
- The heterogeneity among the different studies was found to be modest (i.e., 34%)

@SRMEG_USERN

209 0 0

SRMEG

10 Mar 2020, 20:32

Репост из: Amir Hossein Loghman

#Meta_analysis
#Coronavirus
#COVID_19

🔵 A meta-analysis aimed to investigate whether procalcitonin may play a role in distinguishing patients with or without severe COVID-19

https://www.sciencedirect.com/science/article/pii/S0009898120301066?via%3Dihub

@SRMEG_USERN

211 0 0

SRMEG

9 Mar 2020, 15:46

Репост из: NIIMA, Network of Immunity in Infection, Malignancy and Autoimmunity

Nominating Speakers for USERN 2020

USERN Annual Congress
November 2020 Iran

Nomination via the following link:
https://bit.ly/3cApvm9

@niima_usern
@cip_usern
@srmeg_usern
@usern_net

1.7k 0 0

SRMEG

8 Mar 2020, 20:32

#Migrants
#Mortality
#International

To Migrate or Not To Migrate ⁉️

258 million people reside outside their country of birth; however, to date no global systematic reviews or meta-analyses of mortality data for these international migrants have been done.

🔷 A systematic review and meta-analysis published in Lancet aimed to review and synthesise available mortality data on international migrants.

✅ Meta-analysis has hsown that international migrants have a mortality advantage compared with general populations, and that this advantage persisted across the majority of ICD-10 disease categories.

✅ The mortality advantage identified will be representative of international migrants in high-income countries who are studying, working, or have joined family members in these countries.

✅ The results present an opportunity to reframe the public discourse on international migration and health in high-income countries.

@SRMEG_USERN

https://www.sciencedirect.com/science/article/pii/S0140673618327818

235 0 0

SRMEG

7 Mar 2020, 20:35

#Quarantine
#Review
#COVID19

🔵 Key messages

❎ Information is key; people who are quarantined need to understand the situation
❎ Effective and rapid communication is essential
❎ Supplies (both general and medical) need to be provided
❎ The quarantine period should be short and the duration should not be changed unless in extreme circumstances
❎ Most of the adverse effects come from the imposition of a restriction of liberty; voluntary quarantine is associated with less distress and fewer long-term complications
❎ Public health officials should emphasize the altruistic choice of self-isolating

@SRMEG_USERN

https://www.sciencedirect.com/science/article/pii/S0140673620304608

257 0 0

SRMEG

7 Mar 2020, 20:30

#Quarantine
#Review
#COVID19

⁉️The December, 2019 coronavirus disease outbreak has seen many countries ask people who have potentially come into contact with the infection to isolate themselves at home or in a dedicated quarantine facility. Decisions on how to apply quarantine should be based on the best available evidence. We did a Review of the psychological impact of quarantine using three electronic databases.

⚠️ Most reviewed studies reported negative psychological effects including post-traumatic stress symptoms, confusion, and anger.
⚠️ Stressors included longer quarantine duration, infection fears, frustration, boredom, inadequate supplies, inadequate information, financial loss, and stigma. Some researchers have suggested long-lasting effects.

🚫 In situations where quarantine is deemed necessary, officials should quarantine individuals for no longer than required.
❎ Appeals to altruism by reminding the public about the benefits of quarantine to wider society can be favourable.

@SRMEG_USERN

242 0 0

SRMEG

6 Mar 2020, 14:54

Репост из: NIIMA, Network of Immunity in Infection, Malignancy and Autoimmunity

🔊Call for Application 2020: Contribution in Writing Review Papers and/or Book Chapters

✅There is an opportunity for USERN members, who previously attended scientific writing workshops and published papers, to apply for contribution in writing review papers and/or book chapters in one of the interest groups, supervised by Prof. Nima Rezaei

✏️To apply, please fill the form via the following link:
https://cutt.ly/gttbDqW

❌Deadline for application:
March 15th, 2020

📧You will be contacted by early April, if your application is accepted.

@niima_usern
@srmeg_usern
@cip_usern
@usern_net

4k 0 0

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