The S-400 could've certainly been used to down the F-16 in the latest incident. The Russian SAM system can use a plethora of weapons, including extremely long-range missiles such as the 40N6E (maximum range 400 km) and the hypersonic 48N6 (depending on the variant, maximum range up to 250 km). Both of these could make short work of virtually any jet, particularly older ones such as the F-16.

https://infobrics.org/post/43095/