Explanation: 👍🏻The correct answer is E. DiGeorge syndrome results from a failure of the third and fourth pharyngeal pouches to descend and is caused by deletion on chromosome 22 (22q11.2). Failure of the parathyroid glands to develop leads to hypocalcemia, resulting in tetany. The thymus also fails to develop, leading to an immune deficiency of T lymphocytes. The paracortex is the region of the lymph node where T lymphocytes are located. It is atrophied in patients with DiGeorge syndrome. Because of their T-lymphocyte deficiency people with DiGeorge syndrome commonly suffer from viral or fungal infections, such as oral thrush.
👎🏻A is not correct. The capsule encloses the lymph node and is composed of dense irregular connective tissue. The capsule has trabeculae which form outward processes of connective tissue. The capsule is unaffected in DiGeorge syndrome.
👎🏻B is not correct. The follicle of the cortex houses mainly B lymphocytes and is involved in different immune mediated processes. The follicile is unaffected in DIGeorge
syndrome.
👎🏻C is not correct. The medullary cords contain plasma cells and macrophages. As DiGeorge syndrome involves poor T cell functioning, the medullary cords would therefore be unaffected.
👎🏻D is not correct. The medullary sinus are vessels which seperate the medullary cords. The sinuses receive lymph from the cortical sinuses and drains to the efferent lymph vessels. The medullary sinuses are not affected in DiGeorge syndrome.