#Article 📝
1⃣ Title : Birthweight, genetic risk, and gastrointestinal cancer
incidence: a prospective cohort study
2⃣ Authors : Lu Long , Heng He, Qian Shen, Hongxia Peng,Xiaorui Zhou,Haoxue
Wang,Shanshan Zhang,Shifan Qin, Zequn Lu, Ying Zhu,Jianbo Tian, Jiang
Chang,Xiaoping Miao, Na Shen,and Rong Zhong
3⃣ Abstract in simple language : In the studies that study association between birthweight and genetic factors
with gastrointestinal cancer it includes mouth cancer, esophagus cancer, stomach
cancer, liver cancer, biliary duct cancer, pancreatic cancer, and colorectal cancer
that includes one-quater of the global cancer . researchers used the publicly
available data from UK Biobank ,From 2006 to 2010, the UK Biobank recruited
over 500,000 people aged 40–69 and used multivariate restricted cubic splines
and Cox regression models to estimate the hazard ratios (HRs). This prospective
cohort study interactions between birthweight and PRS(polygenic risk factor) on
gastrointestinal cancer.Was found high birthweight participants with high PRS, gastrointestinal cancer is high. Results demonstrated significant between
gastrointestinal cancer and high genetic risk especially for pancreatic
cancer.Benefits would be obtained from birthweight control, particularly for
individuals with a high genetic risk
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Article Link👩💻 the collector : Maryam Ezzati
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